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Dernières publications
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Dylan Moutachi, Janek Hyzewicz, Pauline Roy, Mégane Lemaitre, Damien Bachasson, et al.. Treadmill running and mechanical overloading improved the strength of the plantaris muscle in the dystrophin‐desmin double knockout (DKO) mouse. The Journal of Physiology, In press, ⟨10.1113/JP286425⟩. ⟨hal-04643936⟩
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Antonio Atalaia, Dagmar Wandrei, Nawel Lalout, Rachel Thompson, Adrian Tassoni, et al.. EURO-NMD registry: federated FAIR infrastructure, innovative technologies and concepts of a patient-centred registry for rare neuromuscular disorders. Orphanet Journal of Rare Diseases, 2024, 19 (1), pp.66. ⟨10.1186/s13023-024-03059-3⟩. ⟨hal-04460667⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
144
Publications avec texte intégral
Open Access
53 %
Mots clés
Myotonic dystrophy mouse models
PacBio
DMPK
GSK3
Myostatin
Dystrophin
Therapy
Male
Trinucleotide repeat expansion
Motoneuron
Brain
Glucocorticoids
Glial cells
Oligodendrocyte
Skeletal muscle
Myelin
Myotonic dystrophy type 1
Trinucleotide Repeat Expansion
Central nervous system
Centronuclear myopathy
Mouse models
Exercice
Dynamin 2
Cardiac muscle
Heart
Cells
Heart failure
CTG repeat instability
Cell model
Intermediate filament
Dystrophie Myotonique
Transgenic mouse model
Oligodendrocytes
Quantitative microdialysis
Transcriptomics
Acetylcholinesterase knockout mouse
Dilated cardiomyopathy
Gene editing
ARN
Gene therapy
Antisense oligonucleotides
Duchenne muscular dystrophy
Autophagy
Astrocytes
Aging
BIOLOGIE MOLECULAIRE
Acetylcholinesterase deficiency
Mouse model
RNA interference
Myotonic Dystrophy type 1
Diaphragm
AAV
Fibrosis
RNA biology
Mice
DMSXL mice
Muscular dystrophy
CRISPR/Cas9
Antisense oligonucleotide
Glutamate
MBNL
Cytoskeleton
Maximal force
Myotonic Dystrophy Type 1
CTG repeat contractions
Genotype phenotype correlation
ACETYLCHOLINESTERASE
Desmin
Transgenic mouse
Endurance training
CTG repeats
Humans
PCR
Long read sequencing
Acute coronary syndrome
Glucocorticoid-receptor
CMS
Cell penetrating peptide
Cultured
CONGENITAL MYATHENIC SYNDROME
Brain dysfunction
GABA
KNOCKOUT MICE
Alternative splicing
RNA splicing
Animals
Myotonic Dystrophy
Muscle
Astrocyte
Exercise
Expression
Cell culture model
Dystrophie myotonique
DM1
Thérapie génique
Gene Therapy
Hypoxia
Myotonic dystrophy
Neuron
CRISPRi